Inducible costimulator costimulates cytotoxic activity and IFN-gamma production in activated murine NK cells.

@article{Ogasawara2002InducibleCC,
  title={Inducible costimulator costimulates cytotoxic activity and IFN-gamma production in activated murine NK cells.},
  author={Kouetsu Ogasawara and Steven K. Yoshinaga and Lewis L. Lanier},
  journal={Journal of immunology},
  year={2002},
  volume={169 7},
  pages={3676-85}
}
The functions of NK cells are regulated by the balance of activating and inhibitory signals. The inhibitory NK cell receptors are well understood; however, less is known about the activating signaling pathways. To explore whether a costimulatory receptor, inducible costimulator (ICOS), is involved in NK cell function, we assessed the role of ICOS in NK cell-mediated cytotoxicity and cytokine production. In addition, to determine whether ICOS contributes to the elimination of tumors in vivo, we… CONTINUE READING

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