Inducible cardiomyocyte-specific deletion of CaM kinase II protects from pressure overload-induced heart failure

@article{Kreusser2016InducibleCD,
  title={Inducible cardiomyocyte-specific deletion of CaM kinase II protects from pressure overload-induced heart failure},
  author={Michael M. Kreusser and Lorenz Lehmann and Nora Wolf and Stanislav Keranov and Andreas Jungmann and Hermann-Josef Gr{\"o}ne and Oliver J M{\"u}ller and Hugo A. Katus and Johannes Backs},
  journal={Basic Research in Cardiology},
  year={2016},
  volume={111},
  pages={1-9}
}
CaM kinase II (CaMKII) has been suggested to drive pathological cardiac remodeling and heart failure. However, the evidence provided so far is based on inhibitory strategies using chemical compounds and peptides that also exert off-target effects and followed exclusively preventive strategies. Therefore, the aim of this study was to investigate whether specific CaMKII inhibition after the onset of cardiac stress delays or reverses maladaptive cardiac remodeling and dysfunction. Combined genetic… CONTINUE READING

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