Inducible beta-lactamases: clinical and epidemiologic implications for use of newer cephalosporins.

@article{Sanders1988InducibleBC,
  title={Inducible beta-lactamases: clinical and epidemiologic implications for use of newer cephalosporins.},
  author={William E. Sanders and Christine C. Sanders},
  journal={Reviews of infectious diseases},
  year={1988},
  volume={10 4},
  pages={830-8}
}
The emergence of resistance to multiple beta-lactam antibiotics is a major problem in patients infected with organisms that characteristically produce inducible beta-lactamases--e.g., species of Pseudomonas, Enterobacter, Serratia, Citrobacter, indole-positive Proteus, and Providencia. Resistance has emerged in 14%-56% of patients infected with these organisms and treated with one of the newer cephalosporins. The emergence of resistance has been associated with clinical failure or relapse in 25… CONTINUE READING