Inducible azole resistance associated with a heterogeneous phenotype in Candida albicans.

@article{Marr2001InducibleAR,
  title={Inducible azole resistance associated with a heterogeneous phenotype in Candida albicans.},
  author={Kieren a. Marr and Chris N Lyons and K Ha and Tige R. Rustad and Theodore C. White},
  journal={Antimicrobial agents and chemotherapy},
  year={2001},
  volume={45 1},
  pages={52-9}
}
The development of azole resistance in Candida albicans is most problematic in patients with AIDS who receive long courses of drug for therapy or prevention of oral candidiasis. Recently, the rapid development of resistance was noted in other immunosuppressed patients who developed disseminated candidiasis despite fluconazole prophylaxis. One of these series of C. albicans isolates became resistant, with an associated increase in mRNA specific for a CDR ATP-binding cassette transporter efflux… CONTINUE READING

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