Inducible and Reversible Clock Gene Expression in Brain Using the tTA System for the Study of Circadian Behavior

@article{Hong2007InducibleAR,
  title={Inducible and Reversible Clock Gene Expression in Brain Using the tTA System for the Study of Circadian Behavior},
  author={Hee-Kyung Hong and J. Chong and W. Song and E. J. Song and Amira A Jyawook and Andrew C. Schook and C. Ko and J. Takahashi},
  journal={PLoS Genetics},
  year={2007},
  volume={3}
}
  • Hee-Kyung Hong, J. Chong, +5 authors J. Takahashi
  • Published 2007
  • Biology, Medicine
  • PLoS Genetics
  • The mechanism of circadian oscillations in mammals is cell autonomous and is generated by a set of genes that form a transcriptional autoregulatory feedback loop. While these “clock genes” are well conserved among animals, their specific functions remain to be fully understood and their roles in central versus peripheral circadian oscillators remain to be defined. We utilized the in vivo inducible tetracycline-controlled transactivator (tTA) system to regulate Clock gene expression… CONTINUE READING

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