Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration.

@article{Chinta2007InducibleAO,
  title={Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration.},
  author={Shankar J Chinta and M. Jyothi Kumar and Michael Hsu and Subramanian Rajagopalan and Deepinder Kaur and Anand Rane and David G. Nicholls and Jinah Choi and Julie K Andersen},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 51},
  pages={13997-4006}
}
Parkinson's disease is a neurodegenerative disorder characterized by the preferential loss of midbrain dopaminergic neurons in the substantia nigra (SN). One of the earliest detectable biochemical alterations that occurs in the Parkinsonian brain is a marked reduction in SN levels of total glutathione (glutathione plus glutathione disulfide), occurring before losses in mitochondrial complex I (CI) activity, striatal dopamine levels, or midbrain dopaminergic neurodegeneration associated with the… CONTINUE READING