Inducible ablation of dopamine D2 receptors in adult mice impairs locomotion, motor skill learning and leads to severe parkinsonism

@article{Bello2017InducibleAO,
  title={Inducible ablation of dopamine D2 receptors in adult mice impairs locomotion, motor skill learning and leads to severe parkinsonism},
  author={Estefan{\'i}a P Bello and Rodrigo Casas-Cordero and Gregorio Luis Gali{\~n}anes and Erica Casey and Mariano A. Belluscio and Victoria Achaval Rodriguez and Daniela Noa{\'i}n and Mario Gustavo Murer and Marcelo Gonçalves Rubinstein},
  journal={Molecular Psychiatry},
  year={2017},
  volume={22},
  pages={595-604}
}
Motor execution and planning are tightly regulated by dopamine D1 and D2 receptors present in basal ganglia circuits. Although stimulation of D1 receptors is known to enhance motor function, the global effect of D2 receptor (D2R) stimulation or blockade remains highly controversial, with studies showing increasing, decreasing or no changes in motor activity. Moreover, pharmacological and genetic attempts to block or eliminate D2R have led to controversial results that questioned the importance… CONTINUE READING
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