Inducible RNA interference-mediated gene silencing using nanostructured gene delivery arrays.

@article{Mann2008InducibleRI,
  title={Inducible RNA interference-mediated gene silencing using nanostructured gene delivery arrays.},
  author={David G. Mann and Timothy E. McKnight and J T Mcpherson and Peter Hoyt and Anatoli V. Melechko and Michael L. Simpson and Gary S. Sayler},
  journal={ACS nano},
  year={2008},
  volume={2 1},
  pages={69-76}
}
RNA interference (RNAi) has become a powerful biological tool over the past decade. In this study, a tetracycline-inducible small hairpin RNA (shRNA) vector system was designed for silencing cyan fluorescent protein (CFP) expression and delivered alongside the yfp marker gene into Chinese hamster ovary cells using impalefection on spatially indexed vertically aligned carbon nanofiber arrays (VACNFs). The VACNF architecture provided simultaneous delivery of multiple genes, subsequent adherence… CONTINUE READING

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