Inducible Nitric Oxide Synthase Induction Underlies Lipid-Induced Hepatic Insulin Resistance in Mice

@inproceedings{Charbonneau2010InducibleNO,
  title={Inducible Nitric Oxide Synthase Induction Underlies Lipid-Induced Hepatic Insulin Resistance in Mice},
  author={Alexandre Charbonneau and Andr{\'e} Marette},
  booktitle={Diabetes},
  year={2010}
}
OBJECTIVE The present study was undertaken to assess the contribution of inducible nitric oxide (NO) synthase (iNOS) to lipid-induced insulin resistance in vivo. RESEARCH DESIGN AND METHODS Wild-type and iNOS(-/-) mice were infused for 6 h with a 20% intralipid emulsion, during which a hyperinsulinemic-euglycemic clamp was performed. RESULTS In wild-type mice, lipid infusion led to elevated basal hepatic glucose production and marked insulin resistance as revealed by impaired suppression of… CONTINUE READING
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