Inducible NO Synthase–Dependent S-Nitrosylation and Activation of Arginase1 Contribute to Age-Related Endothelial Dysfunction

@article{Santhanam2007InducibleNS,
  title={Inducible NO Synthase–Dependent S-Nitrosylation and Activation of Arginase1 Contribute to Age-Related Endothelial Dysfunction},
  author={L. Santhanam and H. Lim and V. Miriel and T. Brown and M. Patel and Sarit Balanson and Sungwoo Ryoo and Mirinda Anderson and K. Irani and F. Khanday and L. Di Costanzo and D. Nyhan and J. Hare and D. Christianson and R. Rivers and A. Shoukas and D. Berkowitz},
  journal={Circulation Research},
  year={2007},
  volume={101},
  pages={692-702}
}
Endothelial function is impaired in aging because of a decrease in NO bioavailability. This may be, in part, attributable to increased arginase activity, which reciprocally regulates NO synthase (NOS) by competing for the common substrate, l-arginine. However, the high Km of arginase (>1 mmol/L) compared with NOS (2 to 20 &mgr;mol/L) seemingly makes direct competition for substrate unlikely. One of the mechanisms by which NO exerts its effects is by posttranslational modification through S… Expand
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