Inducible L-arginine-dependent nitric oxide synthase activity in bovine bone marrow-derived macrophages.

@article{Adler1994InducibleLN,
  title={Inducible L-arginine-dependent nitric oxide synthase activity in bovine bone marrow-derived macrophages.},
  author={Heiko Adler and Ernst Peterhans and Jacques Nicolet and Thomas W. Jungi},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={198 2},
  pages={510-5}
}
In rodent macrophages, cytokines or bacterial constituents induce a Ca(2+)-independent nitric oxide (NO) synthase which plays a key role in antimicrobial and tumoricidal activity. Firm evidence for expression of a similar enzyme in other mammals has been lacking. Here we show that bovine bone marrow-derived macrophages produce nitrite in an L-arginine-dependent manner upon stimulation with heat-killed gram-positive or gram-negative bacteria. NO2- production was markedly diminished by arginase… CONTINUE READING

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