Inducible Caspase9-mediated suicide gene for MSC-based cancer gene therapy

  • Filippo Rossignoli, Giulia Grisendi, +7 authors Massimo Dominici
  • Published 2018 in Cancer Gene Therapy
  • DOI:10.1038/s41417-018-0034-1
Cellular therapies based on mesenchymal stromal/stem cells (MSC) are promising strategies in regenerative medicine and oncology. Despite encouraging results, there is still some level of concerns on inoculating MSC in cancer patients. To face this issue, one possibility resides in engineering MSC by incorporating a suicide gene in order to control their… (More)