Inducible Bronchus-Associated Lymphoid Tissue Elicited by a Protein Cage Nanoparticle Enhances Protection in Mice against Diverse Respiratory Viruses

@inproceedings{Wiley2009InducibleBL,
  title={Inducible Bronchus-Associated Lymphoid Tissue Elicited by a Protein Cage Nanoparticle Enhances Protection in Mice against Diverse Respiratory Viruses},
  author={James A. Wiley and Laura E. Richert and Steve D. Swain and Ann Harmsen and Dale Lynn Barnard and Troy D. Randall and Mark A. Jutila and Trevor Douglas and Chris C Broomell and Mark E. Young and Allen Harmsen},
  booktitle={PloS one},
  year={2009}
}
BACKGROUND Destruction of the architectural and subsequently the functional integrity of the lung following pulmonary viral infections is attributable to both the extent of pathogen replication and to the host-generated inflammation associated with the recruitment of immune responses. The presence of antigenically disparate pulmonary viruses and the emergence of novel viruses assures the recurrence of lung damage with infection and resolution of each primary viral infection. Thus, there is a… CONTINUE READING
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