Inducible, reversible hair loss in transgenic mice

@article{Chen2002InducibleRH,
  title={Inducible, reversible hair loss in transgenic mice},
  author={Jingshan Chen and Max B Kelz and Guoqi Zeng and Cathy Steffen and Penny E. Shockett and Gordon A. Terwilliger and David G Schatz and Eric J Nestler},
  journal={Transgenic Research},
  year={2002},
  volume={11},
  pages={241-247}
}
Telogen effluvium is a common type of hair loss. Although the morphological changes associated with telogen effluvium have been well characterized, the underlying molecular mechanisms remain unknown, and no animal models have been developed. We report here that inducible transgenic mice expressing high levels of the transcription factor, tTA (tetracycline transactivator), plus a reporter luciferase gene, show a reversible hair loss phenotype. Skin of these mice exhibits an increase in the… CONTINUE READING
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