Inducible, pharmacogenetic approaches to the study of learning and memory

@article{Ohno2001InduciblePA,
  title={Inducible, pharmacogenetic approaches to the study of learning and memory},
  author={Masuo Ohno and Paul W. Frankland and Adele Pin Chen and Rui M Costa and Alcino J. Silva},
  journal={Nature Neuroscience},
  year={2001},
  volume={4},
  pages={1238-1243}
}
Here we introduce a strategy in which pharmacology is used to induce the effects of recessive mutations. For example, mice heterozygous for a null mutation of the K-ras gene (K-ras+/−) show normal hippocampal mitogen-activated protein kinase (MAPK) activation, long-term potentiation (LTP) and contextual conditioning. However, a dose of a mitogen-activated/extracellular-signal-regulated kinase (MEK) inhibitor, ineffective in wild-type controls, blocks MAPK activation, LTP and contextual learning… CONTINUE READING
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