Inducible, Dose-Adjustable and Time-Restricted Reconstitution of Stat1 Deficiency In Vivo

@inproceedings{Leitner2014InducibleDA,
  title={Inducible, Dose-Adjustable and Time-Restricted Reconstitution of Stat1 Deficiency In Vivo},
  author={Nicole R. Leitner and Caroline Lassnig and Rita Rom and S. Heider and Zsuzsanna Bag{\`o}-Horvath and Robert Eferl and Simone Mueller and Thomas Kolbe and Lukas Kenner and Thomas R{\"u}licke and Birgit Strobl and Mathias Mueller},
  booktitle={PloS one},
  year={2014}
}
Signal transducer and activator of transcription (STAT) 1 is a key player in interferon (IFN) signaling, essential in mediating host defense against viruses and other pathogens. STAT1 levels are tightly regulated and loss- or gain-of-function mutations in mice and men lead to severe diseases. We have generated a doxycycline (dox) -inducible, FLAG-tagged Stat1 expression system in mice lacking endogenous STAT1 (i.e. Stat1(ind) mice). We show that STAT1 expression depends on the time and dose of… CONTINUE READING

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