Inducibility of E4BP4 suggests a novel mechanism of negative gene regulation by glucocorticoids.

  title={Inducibility of E4BP4 suggests a novel mechanism of negative gene regulation by glucocorticoids.},
  author={Andrew D. Wallace and Thomas T. Wheeler and David A. Young},
  journal={Biochemical and biophysical research communications},
  volume={232 2},
The major biological effects of glucocorticoids are thought to be initiated through changes in the expression of cellular genes. However, the mechanisms involved in the suppression of some gene products by glucocorticoids are not well defined. ID13 mouse fibroblast cells were treated with the synthetic glucocorticoid dexamethasone (Dex) or with vehicle. Plus/ minus (+Dex/-Dex) cDNAs were used to screen an ID13 cDNA library. Using this method, we found that the recently identified human protein… CONTINUE READING

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