Inducers of oxidative stress block ciliary neurotrophic factor activation of Jak/STAT signaling in neurons.

@article{Kaur2005InducersOO,
  title={Inducers of oxidative stress block ciliary neurotrophic factor activation of Jak/STAT signaling in neurons.},
  author={Navjot Kaur and Bingzheng Lu and Richard K Monroe and Scott Matthew Ward and Stanley W. Halvorsen},
  journal={Journal of neurochemistry},
  year={2005},
  volume={92 6},
  pages={1521-30}
}
Generation of reactive oxygen species (ROS) with the accumulation of oxidative damage has been implicated in neurodegenerative disease and in the degradation of nervous system function with age. Here we report that ROS inhibit the activity of ciliary neurotrophic factor (CNTF) in nerve cells. Treatment with hydrogen peroxide (H(2)O(2)) as a generator of ROS inhibited CNTF-mediated Jak/STAT signaling in all cultured nerve cells tested, including chick ciliary ganglion neurons, chick neural… CONTINUE READING
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