Inducer exclusion in Escherichia coli by non-PTS substrates: the role of the PEP to pyruvate ratio in determining the phosphorylation state of enzyme IIAGlc.

@article{Hogema1998InducerEI,
  title={Inducer exclusion in Escherichia coli by non-PTS substrates: the role of the PEP to pyruvate ratio in determining the phosphorylation state of enzyme IIAGlc.},
  author={Boris M Hogema and Jos C. Arents and Rechien Bader and Kevin Eijkemans and Hisashi Yoshida and Homare Takahashi and Hiroji Aiba Aiba and Pieter W. Postma},
  journal={Molecular microbiology},
  year={1998},
  volume={30 3},
  pages={
          487-98
        }
}
The main mechanism causing catabolite repression in Escherichia coli is the dephosphorylation of enzyme IIAGlc, one of the enzymes of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). The PTS is involved in the uptake of a large number of carbohydrates that are phosphorylated during transport, phosphoenolpyruvate (PEP) being the phosphoryl donor. Dephosphorylation of enzyme IIAGlc causes inhibition of uptake of a number of non-PTS carbon sources, a process called inducer… CONTINUE READING
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