Induced sputum inflammatory mediator concentrations in chronic cough.

  title={Induced sputum inflammatory mediator concentrations in chronic cough.},
  author={Surinder S. Birring and Debbie Parker and Christopher Brightling and Peter Bradding and Andrew J. Wardlaw and Ian D. Pavord},
  journal={American journal of respiratory and critical care medicine},
  volume={169 1},
Previous studies have shown evidence of airway inflammation in patients with chronic cough and have suggested that the cough may be due to release of tussive mediators and activation of afferent sensory nerve endings. We measured the concentration of various proinflammatory and tussive mediators in induced sputum supernatants from 20 patients with cough variant asthma or eosinophilic bronchitis, 20 patients with nonasthmatic chronic cough, 22 patients with idiopathic chronic cough, and 18… CONTINUE READING


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