Induced sputum genes associated with spirometric and radiological disease severity in COPD ex-smokers.

@article{Singh2011InducedSG,
  title={Induced sputum genes associated with spirometric and radiological disease severity in COPD ex-smokers.},
  author={Dave Singh and Steven M. Fox and Ruth Tal-Singer and Jonathan Plumb and Stewart A Bates and Peter M Broad and John H. Riley and Bartolome Celli},
  journal={Thorax},
  year={2011},
  volume={66 6},
  pages={489-95}
}
BACKGROUND Induced sputum is used to sample inflammatory cells, predominantly neutrophils and macrophages, from the airways of COPD patients. The author's aim was to identify candidate genes associated with the degree of airflow obstruction and the extent of emphysema by expression profiling, and then to confirm these findings for selected candidates using PCR and protein analysis. METHODS Two sputum studies were performed in Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage… CONTINUE READING