Induced sputum derives from the central airways: confirmation using a radiolabeled aerosol bolus delivery technique.

Abstract

Indirect evidence suggests that induced sputum derives from the surfaces of the bronchial airways. To confirm this experimentally, we employed a radiolabeled aerosol bolus delivery technique that preferentially deposits aerosol in the central airways in humans. We hypothesized that there would be significantly more radioactivity recovered in an induced… (More)

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