Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres.

@article{Goodwin2001InducedSI,
  title={Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres.},
  author={Edward C. Goodwin and Dominick Dimaio},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={2001},
  volume={12 11},
  pages={525-34}
}
Proliferation of normal somatic human cells in culture is limited by replicative senescence, a growth-arrested state that appears to be triggered by the erosion of telomeres. Tumor cells such as HeLa cervical carcinoma cells, which contain short telomeres, can be induced to undergo senescence by various manipulations including oncogene withdrawal. Repression of the human papillomavirus (HPV) type 18 E6/E7 genes in HeLa cells by the bovine papillomavirus E2 transcriptional regulatory protein… CONTINUE READING

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Rapid induction of senescence in human cervical carcinoma cells.

Proceedings of the National Academy of Sciences of the United States of America • 2000
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