Induced recovery of hypoxic phrenic responses in adult rats exposed to hyperoxia for the first month of life.

@article{Fuller2001InducedRO,
  title={Induced recovery of hypoxic phrenic responses in adult rats exposed to hyperoxia for the first month of life.},
  author={D D Fuller and Zun-yi Wang and Liming Ling and Edward Olson and Gerald E. Bisgard and Gordon S Mitchell},
  journal={The Journal of physiology},
  year={2001},
  volume={536 Pt 3},
  pages={917-26}
}
1. Adult rats exposed to hyperoxia for the first month of life have permanently attenuated ventilatory and phrenic nerve responses to hypoxia. We tested the hypothesis that the blunted hypoxic phrenic response in hyperoxia-treated rats (inspired O(2) fraction, F(I,O2) = 0.6 for 28 post-natal days) could be actively restored to normal by intermittent (alternating 12 % O(2)/air at 5 min intervals; 12 h per night for 1 week) or sustained (12 % O(2) for 1 week) hypoxia. 2. Phrenic responses to… CONTINUE READING