Induced preterm birth in sheep: a suitable model for studying the developmental effects of moderately preterm birth.

@article{Matteo2010InducedPB,
  title={Induced preterm birth in sheep: a suitable model for studying the developmental effects of moderately preterm birth.},
  author={Robert De Matteo and Natasha Blasch and Victoria Stokes and Peter C. Davis and Richard Harding},
  journal={Reproductive sciences},
  year={2010},
  volume={17 8},
  pages={
          724-33
        }
}
Our aim was to characterize an ovine model of preterm birth that allows analysis of the developmental effects of preterm birth in the absence of postnatal confounding factors. Preterm birth was induced at 131 days of gestation in 82 lambs; controls (n = 31) were born at term (145 days). Overall survival of preterm lambs was 60%; males had significantly lower survival than females (44% vs 76%); 94% of term lambs survived. Although the birth weight of preterm lambs was approximately 0.9 kg lower… CONTINUE READING

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