Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons.

@article{Dimos2008InducedPS,
  title={Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons.},
  author={John T Dimos and Kit T. Rodolfa and Kathy K. Niakan and Laurin M Weisenthal and Hiroshi Mitsumoto and W. Chung and Gist F. Croft and Genevieve Saphier and Rudy L. Leibel and Robin Goland and Hynek Wichterle and C. E. Henderson and Kevin C. Eggan},
  journal={Science},
  year={2008},
  volume={321 5893},
  pages={1218-21}
}
The generation of pluripotent stem cells from an individual patient would enable the large-scale production of the cell types affected by that patient's disease. These cells could in turn be used for disease modeling, drug discovery, and eventually autologous cell replacement therapies. Although recent studies have demonstrated the reprogramming of human fibroblasts to a pluripotent state, it remains unclear whether these induced pluripotent stem (iPS) cells can be produced directly from… CONTINUE READING
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Via Sforza n 35, 20100 Milan, Italy. 4Milan University, Milan, Italy

Mangiagalli e Regina Elena
2010

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