Induced pluripotent stem cells from familial Alzheimer's disease patients differentiate into mature neurons with amyloidogenic properties.

@article{Mahairaki2014InducedPS,
  title={Induced pluripotent stem cells from familial Alzheimer's disease patients differentiate into mature neurons with amyloidogenic properties.},
  author={Vasiliki Mahairaki and Jiwon Ryu and Ann H. Peters and Qing Chang and Tong Li and Tea Soon Park and Paul W. Burridge and C Conover Talbot and Laura Asnaghi and Lee J. Martin and Elias T. Zambidis and Vassilis E. Koliatsos},
  journal={Stem cells and development},
  year={2014},
  volume={23 24},
  pages={2996-3010}
}
Although the majority of Alzheimer's disease (AD) cases are sporadic, about 5% of cases are inherited in an autosomal dominant pattern as familial AD (FAD) and manifest at an early age. Mutations in the presenilin 1 (PSEN1) gene account for the majority of early-onset FAD. Here, we describe the generation of virus-free human induced pluripotent stem cells (hiPSCs) derived from fibroblasts of patients harboring the FAD PSEN1 mutation A246E and fibroblasts from healthy age-matched controls using… CONTINUE READING
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