Induced pluripotent stem cells from ALS patients for disease modeling.

@article{Richard2015InducedPS,
  title={Induced pluripotent stem cells from ALS patients for disease modeling.},
  author={J. Richard and Nicholas J. Maragakis},
  journal={Brain research},
  year={2015},
  volume={1607},
  pages={15-25}
}
The ability to reprogram adult somatic cells into pluripotent stem cells that can differentiate into all three germ layers of the developing human has fundamentally changed the landscape of biomedical research. For a neurodegenerative disease like Amyotrophic Lateral Sclerosis (ALS), which does not manifest itself until adulthood and is a heterogeneous disease with few animal models, this technology may be particularly important. Induced pluripotent stem cells (iPSC) have been created from… CONTINUE READING