Induced pluripotent stem cells — opportunities for disease modelling and drug discovery

@article{Grskovi2011InducedPS,
  title={Induced pluripotent stem cells — opportunities for disease modelling and drug discovery},
  author={M. Grs̆kovi{\'c} and A. Javaherian and B. Strulovici and G. Daley},
  journal={Nature Reviews Drug Discovery},
  year={2011},
  volume={10},
  pages={915-929}
}
The ability to generate induced pluripotent stem cells (iPSCs) from patients, and an increasingly refined capacity to differentiate these iPSCs into disease-relevant cell types, promises a new paradigm in drug development — one that positions human disease pathophysiology at the core of preclinical drug discovery. Disease models derived from iPSCs that manifest cellular disease phenotypes have been established for several monogenic diseases, but iPSCs can likewise be used for phenotype-based… Expand
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