Induced pluripotent stem cell-derived neural cells survive and mature in the nonhuman primate brain.

@article{Emborg2013InducedPS,
  title={Induced pluripotent stem cell-derived neural cells survive and mature in the nonhuman primate brain.},
  author={Marina E. Emborg and Yan Liu and Jiajie Xi and Xiaoqing Zhang and Yingnan Yin and Jianfeng Lu and Valerie L Joers and Christine Swanson and James E. Holden and Su-chun Zhang},
  journal={Cell reports},
  year={2013},
  volume={3 3},
  pages={646-50}
}
The generation of induced pluripotent stem cells (iPSCs) opens up the possibility for personalized cell therapy. Here, we show that transplanted autologous rhesus monkey iPSC-derived neural progenitors survive for up to 6 months and differentiate into neurons, astrocytes, and myelinating oligodendrocytes in the brains of MPTP-induced hemiparkinsonian rhesus monkeys with a minimal presence of inflammatory cells and reactive glia. This finding represents a significant step toward personalized… CONTINUE READING

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