Induced pluripotency as a potential path towards iNKT cell-mediated cancer immunotherapy

@article{Watarai2012InducedPA,
  title={Induced pluripotency as a potential path towards iNKT cell-mediated cancer immunotherapy},
  author={Hiroshi Watarai and Daisuke Yamada and Shin-ichiro Fujii and Masaru Taniguchi and Haruhiko Koseki},
  journal={International Journal of Hematology},
  year={2012},
  volume={95},
  pages={624-631}
}
Invariant natural killer T (iNKT) cells are characterized by the expression of an invariant Vα14–Jα18 paired with Vβ8/7/2 in mice, and Vα24–Jα18 with Vβ11 in humans, that recognizes glycolipids, such as α-galactosylceramide (α-GalCer), presented on the MHC class I-like molecule, CD1d. iNKT cells act as innate T lymphocytes and serve as a bridge between the innate and acquired immune systems. iNKT cells augment anti-tumor responses by producing IFN-γ, which acts on NK cells to eliminate MHC-non… 

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