Induced oxidative stress and cell death in the A549 lung adenocarcinoma cell line by ionizing radiation is enhanced by supplementation with docosahexaenoic acid.

@article{Kikawa2010InducedOS,
  title={Induced oxidative stress and cell death in the A549 lung adenocarcinoma cell line by ionizing radiation is enhanced by supplementation with docosahexaenoic acid.},
  author={Keith D Kikawa and Jennifer S. Herrick and Roberto Tateo and Michael Mouradian and Justin Yong Soon Tay and Ronald S. Pardini},
  journal={Nutrition and cancer},
  year={2010},
  volume={62 8},
  pages={1017-24}
}
Both ionizing radiation and docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid (PUFA), have been shown to inhibit tumor cell growth at least in part by increasing oxidative stress. In this study, the effects of ionizing radiation, DHA, or a combination of the two on cell proliferation, anchorage-independent growth, apoptosis, and lipid… CONTINUE READING