Induced nitric oxide inhibits IL-6-induced stat3 activation and type II acute phase mRNA expression.

@article{Villavicencio2000InducedNO,
  title={Induced nitric oxide inhibits IL-6-induced stat3 activation and type II acute phase mRNA expression.},
  author={Raphael T Villavicencio and Shubing Liu and Melina R Kibbe and Debra L. Williams and Raymond William Ganster and Kevin F. Dyer and David J Tweardy and Timothy R Billiar and Bruce R. Pitt},
  journal={Shock},
  year={2000},
  volume={13 6},
  pages={441-5}
}
Inducible nitric oxide synthase (iNOS) can be coexpressed with acute phase reactants in hepatocytes; however, it is unknown if NO can regulate the acute phase response. We tested the hypothesis that iNOS-derived nitric oxide (NO) attenuates the acute phase response by inhibiting IL-6-enhanced Stat3 DNA-binding activity and type II acute phase mRNA expression. iNOS was overexpressed in cultured rat hepatocytes via transduction with a replication defective adenovirus containing cDNA for human… CONTINUE READING