Induced multipotency in adult keratinocytes through down-regulation of ΔNp63 or DGCR8.

@article{Chakravarti2014InducedMI,
  title={Induced multipotency in adult keratinocytes through down-regulation of ΔNp63 or DGCR8.},
  author={Deepavali Chakravarti and Xiaohua Su and Min Soon Cho and Ngoc Bao Bui and Cristian Coarfa and Avinashnarayan Venkatanarayan and Ashley L. Benham and Ram{\'o}n E Flores Gonz{\'a}lez and Jennifer L. Alana and Weimin Xiao and Marco L. Leung and Harina Vin and Io Long Chan and Arianexys Aquino and Nicole Mueller and Hongran Wang and Austin John Cooney and Jan V Parker-Thornburg and Kenneth Y. Tsai and Preethi H. Gunaratne and Elsa Renee Flores},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 5},
  pages={E572-81}
}
The roles of microRNAs (miRNAs) and the miRNA processing machinery in the regulation of stem cell biology are not well understood. Here, we show that the p53 family member and p63 isoform, ΔNp63, is a transcriptional activator of a cofactor critical for miRNA processing (DGCR8). This regulation gives rise to a unique miRNA signature resulting in… CONTINUE READING