Induced hyperthermia in sedated humans and the concept of critical thermal maximum.

@article{Bynum1978InducedHI,
  title={Induced hyperthermia in sedated humans and the concept of critical thermal maximum.},
  author={Gaither D. Bynum and Kent B. Pandolf and William H. Schuette and Ralph F. Goldman and David E Lees and Jacqueline Whang-Peng and E R Atkinson and Joan M. C. Bull},
  journal={The American journal of physiology},
  year={1978},
  volume={235 5},
  pages={R228-36}
}
The concept of critical thermal maximum (CTM) has been defined in the literature as the minimal high deep-body temperature that is lethal to an animal. In man the CTM has been estimated at 41.6--42.0 degrees C. Data are presented for sedated, unacclimatized, well-hydrated men heated 1 h at esophageal temperatures of 41.6--42.0 degrees C, without sequelae, except for modest elevation of serum enzymes in two of five patients. These data when combined with other observations in the literature… CONTINUE READING