Induced expression of melittin, an antimicrobial peptide, inhibits infection by Chlamydia trachomatis and Mycoplasma hominis in a HeLa cell line.

@article{Lazarev2002InducedEO,
  title={Induced expression of melittin, an antimicrobial peptide, inhibits infection by Chlamydia trachomatis and Mycoplasma hominis in a HeLa cell line.},
  author={Vassili N. Lazarev and T. M. Parfenova and Samvel K Gularyan and O Yu Misyurina and Tatiana A Akopian and Vadim M. Govorun},
  journal={International journal of antimicrobial agents},
  year={2002},
  volume={19 2},
  pages={133-7}
}
As the number of pathogenic microbial strains resistant to different antibiotics increases, amphipathic peptides with antimicrobial activity are promising agents for the therapy of infectious diseases. This work deals with the effect of an amphipathic antimicrobial peptide, melittin, expressed within recombinant plasmid vectors, on infection with urogenital pathogens Chlamydia trachomatis and Mycoplasma hominis in HeLa cell culture. Recombinant plasmid constructs with the melittin gene under… CONTINUE READING
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