Induced differentiation of K562 leukemia cells: a model for studies of gene expression in early megakaryoblasts.

@article{Alitalo1990InducedDO,
  title={Induced differentiation of K562 leukemia cells: a model for studies of gene expression in early megakaryoblasts.},
  author={Riitta Alitalo},
  journal={Leukemia research},
  year={1990},
  volume={14 6},
  pages={501-14}
}
The K562 leukemia cell line has been extensively used in studies of erythroid differentiation but it has been less well appreciated that treatment of K562 cells with the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) leads to loss of their erythroid properties and to acquisition of several megakaryoblastoid characteristics. These include synthesis and surface expression of glycoprotein IIIa, an increase in platelet peroxidase positivity, enhancement of thromboxane A2 receptors, and… CONTINUE READING