Induced chromosome deletion in a Williams-Beuren syndrome mouse model causes cardiovascular abnormalities.

@article{Goergen2011InducedCD,
  title={Induced chromosome deletion in a Williams-Beuren syndrome mouse model causes cardiovascular abnormalities.},
  author={Craig J. Goergen and Hong-Hua Li and Uta Francke and Charles A. Taylor},
  journal={Journal of vascular research},
  year={2011},
  volume={48 2},
  pages={119-29}
}
AIMS The Williams-Beuren syndrome (WBS) is a genetic disorder caused by a heterozygous ~1.5-Mb deletion. The aim of this study was to determine how the genetic changes in a Wbs mouse model alter Eln expression, blood pressure, vessel structure, and abdominal aortic wall dynamics in vivo. METHODS Elastin (ELN) transcript levels were quantified by qRT-PCR and blood pressure was measured with a tail cuff system. M-mode ultrasound was used to track pulsatile abdominal aortic wall motion. Aortas… CONTINUE READING

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