Induced and sustained hypernatremia for the prevention and treatment of cerebral edema following brain injury.

@article{Ryu2013InducedAS,
  title={Induced and sustained hypernatremia for the prevention and treatment of cerebral edema following brain injury.},
  author={Justine H Ryu and Brian Patrick Walcott and Kristopher Thomas Kahle and Sameer A. Sheth and Randall T. Peterson and Brian Vala Nahed and Jean-Valery C. E. Coumans and J. Marc Simard},
  journal={Neurocritical care},
  year={2013},
  volume={19 2},
  pages={222-31}
}
Cerebral edema develops in response to and as a result of a variety of neurologic insults such as ischemic stroke, traumatic brain injury, and tumor. It deforms brain tissue, resulting in localized mass effect and increase in intracranial pressure (ICP) that are associated with a high rate of morbidity and mortality. When administered in bolus form, hyperosmolar agents such as mannitol and hypertonic saline have been shown to reduce total brain water content and decrease ICP, and are currently… CONTINUE READING
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