Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

@article{Dimos2008InducedPS,
  title={Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons},
  author={John T. Dimos and Kit T. Rodolfa and Kathy K. Niakan and Laurin M. Weisenthal and Hiroshi Mitsumoto and Wendy K. Chung and Gist Croft and Genevieve Saphier and Rudolph L. Leibel and Robin Goland and Hynek Wichterle and Christopher E. Henderson and Kevin C Eggan},
  journal={Science},
  year={2008},
  volume={321},
  pages={1218 - 1221}
}
The generation of pluripotent stem cells from an individual patient would enable the large-scale production of the cell types affected by that patient's disease. These cells could in turn be used for disease modeling, drug discovery, and eventually autologous cell replacement therapies. Although recent studies have demonstrated the reprogramming of human fibroblasts to a pluripotent state, it remains unclear whether these induced pluripotent stem (iPS) cells can be produced directly from… 
Induced pluripotent stem cells from ALS patients for disease modeling
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The progress made via the use of patient‐derived iPS cells toward the modeling of neurological disorders, the testing of existing drugs, and the discovery of new drugs are outlined.
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[Neuronal cells derived from induced pluripotent stem cells to model motoneuron diseases].
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Recent progress in the use of disease-specific iPSCs for in vitro and in vivo modeling of neurological diseases is reviewed.
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