Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

  title={Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells},
  author={J. Yu and M. Vodyanik and K. Smuga-Otto and Jessica Antosiewicz-Bourget and Jennifer L Frane and S. Tian and Jeff Nie and Gudrun A. Jonsdottir and Victor Ruotti and R. Stewart and I. Slukvin and J. Thomson},
  pages={1917 - 1920}
  • J. Yu, M. Vodyanik, +9 authors J. Thomson
  • Published 2007
  • Biology
  • Science
  • Somatic cell nuclear transfer allows trans-acting factors present in the mammalian oocyte to reprogram somatic cell nuclei to an undifferentiated state. We show that four factors (OCT4, SOX2, NANOG, and LIN28) are sufficient to reprogram human somatic cells to pluripotent stem cells that exhibit the essential characteristics of embryonic stem (ES) cells. These induced pluripotent human stem cells have normal karyotypes, express telomerase activity, express cell surface markers and genes that… CONTINUE READING
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