Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

@article{Yu2007InducedPS,
  title={Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells},
  author={Junying Yu and Maxim A. Vodyanik and Kim Smuga-Otto and Jessica Antosiewicz-Bourget and Jennifer L. Frane and Shulan Tian and Jeff Nie and Gudrun A. Jonsdottir and Victor Ruotti and Ron M. Stewart and Igor I. Slukvin and James A. Thomson},
  journal={Science},
  year={2007},
  volume={318},
  pages={1917 - 1920}
}
Somatic cell nuclear transfer allows trans-acting factors present in the mammalian oocyte to reprogram somatic cell nuclei to an undifferentiated state. [] Key Result These induced pluripotent human stem cells have normal karyotypes, express telomerase activity, express cell surface markers and genes that characterize human ES cells, and maintain the developmental potential to differentiate into advanced derivatives of all three primary germ layers. Such induced pluripotent human cell lines should be useful…

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