Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

@article{Yu2007InducedPS,
  title={Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells},
  author={Junying Yu and Maxim A. Vodyanik and Kim Smuga-Otto and Jessica Antosiewicz-Bourget and Jennifer L. Frane and Shulan Tian and Jeff Nie and Gudrun A. Jonsdottir and Victor Ruotti and Ron M. Stewart and Igor I. Slukvin and James A. Thomson},
  journal={Science},
  year={2007},
  volume={318},
  pages={1917 - 1920}
}
Somatic cell nuclear transfer allows trans-acting factors present in the mammalian oocyte to reprogram somatic cell nuclei to an undifferentiated state. [] Key Result These induced pluripotent human stem cells have normal karyotypes, express telomerase activity, express cell surface markers and genes that characterize human ES cells, and maintain the developmental potential to differentiate into advanced derivatives of all three primary germ layers. Such induced pluripotent human cell lines should be useful…

Monitoring Multiple Pluripotency Biomarkers After Delivery of Reprogramming Factors to Human Somatic Cells

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Reprogramming of human somatic cells to pluripotency with defined factors

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Late Passage Human Fibroblasts Induced to Pluripotency Are Capable of Directed Neuronal Differentiation

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Induced Pluripotent Stem Cells Generated Without Viral Integration

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Mouse induced pluripotent stem cells.

The recent discovery that it is possible to directly reprogramme somatic cells to an embryonic stem (ES) cell-like pluripotent state, by retroviral transduction of just four genes represents a major breakthrough in stem cell research.

Induced pluripotent stem (iPS) cells from human fetal stem cells.

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