Induced Malignancy in Cells from Rat Myocardium Subjected to Intermittent Anaerobiosis during Long Propagation in Vitro

@article{Goldblatt1953InducedMI,
  title={Induced Malignancy in Cells from Rat Myocardium Subjected to Intermittent Anaerobiosis during Long Propagation in Vitro},
  author={Harry Goldblatt and Gladys Cameron},
  journal={The Journal of Experimental Medicine},
  year={1953},
  volume={97},
  pages={525 - 552}
}
In two strains of fibroblasts originating from fragments of myocardium from a 5 day old rat of the Slonaker-Addis strain, a strain known to develop tumors but rarely, abnormal morphologic alterations took place which eventuated in neoplastic changes. This happened only after repeated exposure of the cultures to an atmosphere of nitrogen (anaerobiosis) and… CONTINUE READING