Induced HMGA1a expression causes aberrant splicing of Presenilin-2 pre-mRNA in sporadic Alzheimer's disease

@article{Manabe2003InducedHE,
  title={Induced HMGA1a expression causes aberrant splicing of Presenilin-2 pre-mRNA in sporadic Alzheimer's disease},
  author={Takayuki Manabe and Taiichi Katayama and Noriko Sato and Fujiya Gomi and Junichi Hitomi and Takeshi Yanagita and Takashi Kudo and Akira Honda and Yasutake Mori and Shinsuke Matsuzaki and Kazunori Imaizumi and Akila Mayeda and Masaya Tohyama},
  journal={Cell Death and Differentiation},
  year={2003},
  volume={10},
  pages={698-708}
}
AbstractThe aberrant splicing isoform (PS2V), generated by exon 5 skipping of the Presenilin-2 (PS2) gene transcript, is a diagnostic feature of sporadic Alzheimer's disease (AD). We found PS2V is hypoxia-inducible in human neuroblastoma SK-N-SH cells. We purified a responsible trans-acting factor based on its binding to an exon 5 fragment. The factor was identified as the high mobility group A1a protein (HMGA1a; formerly HMG-I). HMGA1a bound to a specific sequence on exon 5, located upstream… CONTINUE READING
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