Induced Fit or Conformational Selection? The Role of the Semi-closed State in the Maltose Binding Protein

@inproceedings{Bucher2011InducedFO,
  title={Induced Fit or Conformational
Selection? The Role of the Semi-closed State in the Maltose Binding Protein},
  author={Denis Bucher and Barry J. Grant and James Andrew McCammon},
  booktitle={Biochemistry},
  year={2011}
}
A full characterization of the thermodynamic forces underlying ligand-associated conformational changes in proteins is essential for understanding and manipulating diverse biological processes, including transport, signaling, and enzymatic activity. Recent experiments on the maltose binding protein (MBP) have provided valuable data about the different conformational states implicated in the ligand recognition process; however, a complete picture of the accessible pathways and the associated… CONTINUE READING

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