Induced Differentiation of Human Myeloid Leukemia Cells into M2 Macrophages by Combined Treatment with Retinoic Acid and 1α,25-Dihydroxyvitamin D3

@inproceedings{Takahashi2014InducedDO,
  title={Induced Differentiation of Human Myeloid Leukemia Cells into M2 Macrophages by Combined Treatment with Retinoic Acid and 1α,25-Dihydroxyvitamin D3},
  author={Hiromichi Takahashi and Yoshihiro Hatta and Noriyoshi Iriyama and Yuichiro Hasegawa and Hikaru Uchida and Masaru Nakagawa and Makoto Makishima and Jin Takeuchi and Masami Takei},
  booktitle={PloS one},
  year={2014}
}
Retinoids and 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) induce differentiation of myeloid leukemia cells into granulocyte and macrophage lineages, respectively. All-trans retinoic acid (ATRA), which is effective in the treatment of acute promyelocytic leukemia, can induce differentiation of other types of myeloid leukemia cells, and combined treatment with retinoid and 1,25(OH)2D3 effectively enhances the differentiation of leukemia cells into macrophage-like cells. Recent work has classified… CONTINUE READING
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