Indoxyl sulfate stimulates proliferation of rat vascular smooth muscle cells.

@article{Yamamoto2006IndoxylSS,
  title={Indoxyl sulfate stimulates proliferation of rat vascular smooth muscle cells.},
  author={Hiroyuki Yamamoto and Shuichi Tsuruoka and Tomoko Ioka and Hideyuki Ando and Chiharu Ito and Tetsu Akimoto and Akio Fujimura and Yasushi Asano and Eiji Kusano},
  journal={Kidney international},
  year={2006},
  volume={69 10},
  pages={
          1780-5
        }
}
Vascular smooth muscle cell (VSMC) proliferation is a key event in the progression of arteriosclerosis. Clinical studies show that uremic toxins deteriorate the arteriosclerosis in renal failure patients. Indoxyl sulfate (IS) is a strong protein-bound uremic toxin, but the effect of IS on VSMC proliferation has not been studied. We examined the effect of IS on rat VSMC proliferation, assessed by a cell counting kit (4-[3-[4-lodophenyl]-2-4(4-nitrophenyl)-2H-5-tetrazolio-1,3-benzene disulfonate… CONTINUE READING

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