Indoxyl sulfate induces leukocyte-endothelial interactions through up-regulation of E-selectin.

@article{Ito2010IndoxylSI,
  title={Indoxyl sulfate induces leukocyte-endothelial interactions through up-regulation of E-selectin.},
  author={Shunsuke Ito and Mizuko Osaka and Yusuke Higuchi and Fuyuhiko Nishijima and Hideto Ishii and Masayuki Yoshida},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 50},
  pages={38869-75}
}
Despite a positive correlation between chronic kidney disease and atherosclerosis, the causative role of uremic toxins in leukocyte-endothelial interactions has not been reported. We thus examined the effects of indoxyl sulfate, a uremic toxin, on leukocyte adhesion to activated endothelial cells and the underlying mechanisms. Pretreatment of human umbilical vein endothelial cells (HUVEC) with indoxyl sulfate significantly enhanced the adhesion of human monocytic cells (THP-1 cell line) to TNF… CONTINUE READING