Indoxyl sulfate induces complex redox alterations in mesangial cells.

@article{Gelasco2006IndoxylSI,
  title={Indoxyl sulfate induces complex redox alterations in mesangial cells.},
  author={Andrew K. Gelasco and John R. Raymond},
  journal={American journal of physiology. Renal physiology},
  year={2006},
  volume={290 6},
  pages={
          F1551-8
        }
}
Indoxyl sulfate is a protein metabolite that is concentrated in the serum of patients with chronic renal insufficiency. It also is a uremic toxin that has been implicated in the progression of chronic renal disease in rodent models. We have shown previously that mesangial cell redox status is related to activation of mitogen-activated protein kinases and cell proliferation, which are factors related to glomerular damage. We used three methods to examine the ability of indoxyl sulfate to alter… CONTINUE READING

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