Indomethacin treatment of rats with dimethylhydrazine-induced intestinal tumors.

@article{Pollard1980IndomethacinTO,
  title={Indomethacin treatment of rats with dimethylhydrazine-induced intestinal tumors.},
  author={Morris Pollard and Phyllis H. Luckert},
  journal={Cancer treatment reports},
  year={1980},
  volume={64 12},
  pages={1323-7}
}
Intestinal tumors were induced in male Sprague-Dawley rats following the administration of five weekly doses of 1,2-dimethylhydrazine (DMH) by gavage. At intervals thereafter, groups of rats were given indomethacin (IND) in the drinking water. In three trials, the incidence of rats with tumors was significantly reduced by 40% below the control rats which… CONTINUE READING